The play came on a fourth down as San Francisco opted to be aggressive early. He has completed 113-of-165 passes (68.4 percent) while throwing 14 touchdown passes and three interceptions, including nine touchdown passes in his last two games.
But the double-threat quarterback was solid when it counted.
Under intense pressure, Chuck Clark stripped the ball from Garoppolo and Brandon Williams recovered at San Francisco's 23-yard line. They have the MVP frontrunner, quarterback Lamar Jackson.
Mostert finished the game with a career-high 146 yards on 19 carries to go along with his score. The good news for Baltimore is that the run game is its offensive specialty, and San Francisco is in the middle of the pack there at 16th in DVOA.
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On Justin Tucker's 49-yard game-winning field goal as time expired, Baltimore (10-2) beat the NFC's top team for its franchise-best eighth straight win and extended its run over the league's elite.
On the very first drive of the game, the 49ers took the lead through a fantastic, leaping 33-yard touchdown grab from Deebo Samuel as he rose above Marcus Peters to secure the catch.
After the Ravens were forced to punt for the first time since Week Nine under Jackson (21 drives), their defense made a play to get back in it. He twice has posted a flawless passer rating (158.3) and now leads the league with 30 touchdowns (24 passing and six rushing). In fact, both the 49ers (10-1) and Ravens head into their Week 13 showdown just days removed from wins of at least 28 points against winning teams, which is a first in National Football League history.
On the flip side, Kyle Shanahan and the 49ers offense have enjoyed the run, as well; the Niners rank second in rush YPG (145.6), are tied for the second-most rush TDs (15) and boast arguably the best RB depth in the NFL. Cornerback will return after missing the past six games with a knee injury.